PSY FPX 6110 Assessment 1 Annotated Bibliography-Psychedelic Therapy Studies
Phillip April 25, 2024 No Comments

PSY FPX 6110 Assessment 1 Annotated Bibliography-Psychedelic Therapy Studies

PSY FPX 6110 Assessment 1 Annotated Bibliography-Psychedelic Therapy Studies


Capella university

PSY FPX 6110 Learning Theories in Psychology

Prof. Name


Annotated Bibliography

Davis, A. K., So, S., Lancelotta, R., Barsuglia, J. P., & Griffiths, R. R. (2019). 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) used in a naturalistic group setting is associated with unintended improvements in depression and anxiety. The American Journal of Drug and Alcohol Abuse, 45(2), 161–169.

Davis, So, Lancelotta, Barsuglia, and Griffiths (2019) investigated the utilization of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a communal setting, revealing unintended ameliorations in depression and anxiety. The study analyzed self-reported levels of depression and anxiety among individuals consuming 5-MeO-DMT in a group environment characterized by structured dosing, procedures, and support mechanisms. The findings suggested that following the use of 5-MeO-DMT, there were reported improvements in symptoms of depression and anxiety among participants. These improvements were associated with increased spiritual significance and personal meaning attributed to the experience.

Duerler, P., Schilbach, L., Stämpfli, P., Vollenweider, F. X., & Preller, K. H. (2020). LSD-induced increases in social adaptation to opinions similar to one’s own are associated with stimulation of serotonin receptors. Scientific Reports, 10(1), 12181.

PSY FPX 6110 Assessment 1 Annotated Bibliography-Psychedelic Therapy Studies

Duerler et al. (2020) investigated the impact of LSD on social adaptation to opinions congruent with one’s own, elucidating the role of serotonin receptors in social influence processing. The double-blind random crossover study involved 24 volunteers who received either a placebo, LSD (100 micrograms), or a 5HT2A receptor antagonist plus LSD (100 micrograms) over three sessions. The results indicated that LSD facilitated social adaptation, particularly when individuals encountered opinions aligned with their own. This effect was correlated with heightened activity in the ventral medial prefrontal cortex during social feedback processing, providing insights into the neuropharmacological mechanisms underlying social cognitive behavior.

Forstmann, M., Yudkin, D. A., Prosser, A. M., Heller, S. M., & Crockett, M. J. (2020). Transformative experience and social connectedness mediate the mood-enhancing effects of psychedelic use in naturalistic settings. Proceedings of the National Academy of Sciences, 117(5), 2338–2346.

Forstmann et al. (2020) examined the mediating roles of transformative experiences and social connectedness in the mood-enhancing effects of psilocybin and other psychedelics in naturalistic settings. The three-year study, comprising 1,225 participants across multiple mass gatherings, employed field studies and questionnaire assessments. The findings suggested that recent psychedelic use was associated with heightened transformative experiences and social connectedness, which in turn mediated improvements in positive mood. This study underscores the potential of psychedelics to induce personal transformation and enhance social cohesion in naturalistic settings, with ethical approval from the Oxford Central Research Ethics Committee.

PSY FPX 6110 Assessment 1 Annotated Bibliography-Psychedelic Therapy Studies

Griffiths, R. R., Johnson, M. W., Carducci, M. A., Umbricht, A., Richards, W. A., Richards, B. D., Cosimano, M. P., & Klinedinst, M. A. (2016). Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial. Journal of Psychopharmacology (Oxford), 30(12), 1181–1197.

Griffiths et al. (2016) investigated the effects of psilocybin on depression and anxiety symptoms in cancer patients through a randomized double-blind trial. The study involved 51 patients with life-threatening diagnoses who received either a low or high dose of psilocybin in a cross-over design. Significant reductions in depression and anxiety, coupled with increased life meaning and optimism, were observed following high-dose psilocybin administration. These effects were sustained at the 6-month follow-up, suggesting the therapeutic potential of psilocybin in alleviating psychological distress in cancer patients.

Mitchell, J. M., Bogenschutz, M., Lilienstein, A., Harrison, C., Kleiman, S., Parker-Guilbert, K., Ot’alora G, M., Garas, W., Paleos, C., Gorman, I., Nicholas, C., Mithoefer, M., Carlin, S., Poulter, B., Mithoefer, A., Quevedo, S., Wells, G., Klaire, S. S., van der Kolk, B., Tzarfaty, K., … Doblin, R. (2021). MDMA-assisted therapy for severe PTSD: A randomized, double-blind, placebo-controlled phase 3 study. Nature Medicine, 27(6), 1025–1033.

PSY FPX 6110 Assessment 1 Annotated Bibliography-Psychedelic Therapy Studies

Mitchell et al. (2021) conducted a phase 3 trial to assess the efficacy and safety of MDMA-assisted therapy for severe PTSD. Ninety participants were randomized to receive either MDMA therapy or a placebo, alongside preparatory and integrative sessions. Significant reductions in PTSD symptoms were observed in the MDMA group compared to the placebo, with some patients achieving remission after just one or two sessions. This study highlights the promising therapeutic potential of MDMA-assisted therapy in individuals with severe PTSD, warranting further clinical evaluation.